Science blasphemed when tries to eliminate scarcity in economy.
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NASA astronauts have only managed to live continuously on the International Space Station (ISS) for a year and Biosphere 2 on Earth failed at two years of uninterrupted human habitation. Both cases required extracting the sickened people from the toxic environments. At this point it is ludicrous to talk about a permanent manned base on Mars.
The scandal with the Thirty Meter Telescope (TMT) atop Mauna Kea is how it managed to obtain a construction permit to build a manned telescope in a known biologically toxic environment to workers. How many more people need to die, get injured or develop long term very high altitude sickness that will last a lifetime?